发给老马备查:
/ g: T1 c0 b! ?滴水察海(69304838) 15:23:238 p6 g, u9 J! j6 [
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
, I+ r, f: T0 i1 z/ p* [* B吉非替尼和S-1连用的依据
. H: q1 a/ a8 h% yGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
. f! R( e; q! ?1 x+ M: K& P是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
* Z( x; C3 J( A x: X这样是不是推理出,耐药后,可以用S-1和培美了?
* h: x X* c( u( C8 C: K/ e' R结论:2 m) U* l" M- L' J: D- a
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |